Web451 Background: Patients (pts) with mUC who are ineligible to receive cisplatin have limited treatment options. Pembrolizumab and atezolizumab were approved as 1st-line therapy … WebNov 12, 2024 · 2.4 Eligibility of cisplatin-based chemotherapy Because of the population difference, we used the modified cisplatin-ineligible criteria of Galsky et al.24 Using the original criteria, a patient defined as cisplatin ineligible would meet at least one of the following criteria: ECOG PS > 1, creatinine clearance <60 ml/min or eGFR
Defining cisplatin eligibility in patients with muscle ... - PubMed
WebJan 11, 2024 · The first cisplatin ineligibility criteria for patients with metastatic bladder cancer were proposed by Galsky et al. in 2011 (ref. 47) and defined as any one of the … WebMar 15, 2024 · Dr. Gupta: When we use the Galsky criteria, it excludes up to 50% of patients from receiving cisplatin just based on the creatinine clearance of 60 mL/min … twisted urethra symptoms
Dr. Galsky the Evolution of Standard Options in Urothelial
WebMar 28, 2024 · In the 1L setting, utilizing cisplatin-eligibility criteria, including Galsky criteria and geriatric assessments as above, if a patient is fit for cisplatin-based chemotherapy, gemcitabine plus cisplatin is the optimal 1L therapy followed by avelumab maintenance. For those patients deemed unfit for cisplatin, a more careful assessment … WebDec 20, 2024 · Cisplatin eligibility was determined based on Galsky criteria, which includes glomerular filtration rate >60 mL/min, ECOG performance status 0 to 1, congestive heart failure New York Heart Association (NYHA) class ≤ III and neuropathy/hearing loss grade ≤2. 15. Median follow-up duration was calculated using the Kaplan-Meier method … WebJan 14, 2024 · Cisplatin eligibility criteria are defined for patients with metastatic bladder cancer by the Galsky criteria, which include creatinine clearance ≥60 ml/min. However, consensus is still lacking regarding cisplatin eligibility criteria in the neoadjuvant, curative MIBC setting, which continues to represent a substantial barrier to the ... take dress off country song