WebApr 25, 2024 · We previously reported the results of a phase 1 and phase 2 trial of a clofarabine-based regimen with topotecan, vinorelbine, and thiotepa (TVTC) in a cohort of patients with relapsed acute leukemias. 11,12 In the phase 2 study, 8 (67%) of 12 patients with relapsed or refractory (R/R) AML achieved a complete response (CR) or complete … WebThiotepa (also known as Thioplex ®) is an anticancer medicine. It is a clear liquid given by vein (IV). Thiotepa can pose a health hazard to caregivers. All caregivers should take safety precautions while giving this drug. For 48 hours after this drug is given, the patient’s body fluids can contain the drug.
Outcomes Associated With Thiotepa-Based Conditioning in …
WebOct 26, 2024 · Thiotepa is an established component of ASCT conditioning regimens for CNS lymphoma, it has recently been incorporated into multiagent chemotherapy regimens, 7 although the dose used in the MATRix regimen (30 mg/m 2) was empirically adopted … WebTumor-bearing mice were treated with high-dose melphalan or cyclophosphamide followed 7 or 12 days later by melphalan, cyclophosphamide, thiotepa, or carboplatin. After … boland bottling worcester
THIOTEPA - Pharmaceuticals - NCBI Bookshelf
WebApr 2, 2024 · Thiotepa for Injection, USP is an ethylenimine-type compound. It is supplied as a non-pyrogenic, sterile Iyophilized powder for intravenous, intracavitary or intravesical administration, containing 15 mg of thiotepa. Thiotepa is a synthetic product with antitumor activity. The chemical name for thiotepa is Tris (1-aziridinyl)phosphine sulfide. WebOct 15, 2007 · Thiotepa is a phase nonspecific polyfunctional alkylating agent (i.e., more than one reactive ethylenimine group). It is chemically and pharmacologically related to … WebThiotepa (Tepadina) Thiotepa is a chemotherapy drug. It is mainly used to prepare people for a bone marrow transplant. How does thiotepa work? Thiotepa is a type of drug called an alkylating agent. It works by sticking to 1 of the cancer cell's DNA strands. Then the cell can't divide into 2 new cells. gluten free campbell soups