WebNational Center for Biotechnology Information WebJan 11, 2024 · TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay. Properties Spectrum Names Name TMP778 TMP778 Biological Activity Chemical & Physical Properties No Any Chemical & Physical Properties

TMP778 CAS#:1422171-08-1 Chemsrc

TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC50 of 0.03 μM [1] . TMP920 (0.09-30 μM) starts to show toxic effects on cell growth at >10 μM in Naïve CD4 + T cells [1]. WebFor iTreg cell conversion, TGF-β1 (5 ng/ml) was added into the cultures. RORγt inhibitors (TMP778, 2.5 μM; TMP920, 10 μM; Digoxin, 10 μM) or vehicle control DMSO was also included in the cultures, or as indicated in figure legends. After 96 h, cells were collected for further experiments. Growth protocol paris hotel roma

TMP920 MedChemExpress Life Science Reagents

WebOct 15, 2024 · Remarkable insights into activity of different RORγt inhibitors including TMP778, TMP920, and GSK805 induced alteration of gene occupancy in RORγt was investigated by Xiu et al., 2014 that predicted the activity of RORγt inhibitors based on genome-wide chromatin immunoprecipitation sequencing and RNA-sequencing. WebTMP920: Data processing: Illumina Casava1.7 software used for basecalling. RNA-seq reads were aligned to the NCBI Build 37 (UCSC mm9) of the mouse genome using TopHat (Trapnell et al., 2009). The resulting alignments were processed by Scripture (Guttman et al., 2010) to evaluate the expression of transcripts from RefSeq (Pruitt et al., 2007). ... http://www.signalingpathways.org/datasets/index.jsf?doi=10.1621/XxZLsPiGSH timetabling kcl.ac.uk