Topbp1 rad51
Web15. jan 2024 · We found that TopBP1 deletion caused reduced testis size, reduced epididymal sperm numbers, increased apoptosis, and severely compromised fertility. Loss … WebMechanistically, TOPBP1 physically binds PLK1 and promotes PLK1 kinase–mediated phosphorylation of RAD51 at serine 14, a modification required for RAD51 recruitment to chromatin. Overall, our results provide mechanistic insights into TOPBP1’s role in HR, with potential clinical implications for cancer treatment.
Topbp1 rad51
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Web1. feb 2016 · TOPBP1 is a key player in DNA replication and DNA damage signaling. In this issue, Moudry et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201507042) uncover … Web7. feb 2011 · It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR. Class Genetic Information Processing; Replication and repair BRITE hierarchy Pathway map
Web25. jan 2016 · Because RAD51 phosphorylation at serine 14 and threonine 13 facilitates RAD51 recruitment to IR-induced damage sites (Yata et al., 2012), absence of RAD51 … WebThese panels are a focused compilation of genes based on their role in a biological process, disease, or pathway. Targets represent a diverse set of signaling molecules as well as upstream and downstream effectors. Panels were modeled after SAB PCR arrays and utilize PrimePCR expertly designed and experimentally validated assays.
Web31. aug 2024 · Mechanistically, CIP2A was discovered genome-widely the closest functional homologue for DNA-damage proteins TopBP1, RHNO, POLQ, NBN and PARP1. CIP2A … Web5. nov 2024 · TopBP1 is the stimulator of ATR activity, as it has an ATR activation domain (AD), while the 9-1-1 complex is the recruiter of TopBP1, and the RAD17-RFC complex is the loader of the 9-1-1 complex as a junction between ssDNA and dsDNA.
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Web1. máj 2024 · TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome … gestlat therapy brisbaneWeb20. máj 2024 · TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity. Moudry P , Watanabe K , Wolanin KM , Bartkova J , … gesti windows 11Web25. jan 2016 · DNA strand breakage, one of the main types of DNA damage, enables Topoisomerase II-binding protein 1 (TopBP1) to induce ATR-Chk1 mediated checkpoint … gest lease illkirchWeb10. jan 2024 · a Western blot analysis of TopBP1, RAD51, and GAPDH levels in HFK-, HFK-31-, and HPV31-positive CIN612 cells differentiated in high-calcium media for the … christmas greetings gifWeb14. apr 2024 · Following the binding of MDC1 (mediator of DNA damage checkpoint protein 1) to γH2AX, TOPBP1-ATR is further activated and confined to the sex body and promotes the γH2AX signal spread to the protruding loops of the chromatin at the mid-pachytene stage ( Ichijima et al., 2011; ElInati et al., 2024 ). gest newfoundlandWeb1. máj 2024 · The localization of HTATSF1-TOPBP1 to DSBs is potentially independent of the transcription-coupled RNA-binding and processing capacity of HTATSF1 but rather … gestocat idealistagest majority minority